The primary methyltransferase responsible for m7G modification is METTL1 (methyltransferase‐like 1), which targets mRNAs, while WDR4 (WD repeat domain 4) facilitates the binding of the heterodimeric complex to target mRNAs, influencing cancer development by regulating m7G methylation.78 This evidence concerns the gene WDR4 and cancer.