There are several primary approaches for immunotherapy of sepsis in current research and clinical practice: Cytokine therapy, some cytokines such as granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), IFN‐γ, IL‐7, and IL‐15, can modulate immune cell functions and assist in reversing the immunosuppressive state in septic patients. Here, CSF2 is linked to Sepsis.