Conversely, when YTHDF2 expression was reduced, the inhibitory impacts on proliferation, anti‐apoptosis, migration, invasion, and stemness in QBC939 cells could be reversed by the overexpression of SOX2, which in turn exacerbated the malignant biological behaviors of CCA (Figure 5F–J). The gene discussed is YTHDF2; the disease is cholangiocarcinoma.