A time‐course following treatment with actinomycin D showed that siRNA‐mediated knockdown of YTHDF2 specifically reduced the stability of SOX2 mRNA in CCLP‐1 cells with little effect on HIBEC (Figure S3G), thus indicating a CCA‐specific dependency where YTHDF2 supports cholangiocarcinoma cells. The gene discussed is SOX2; the disease is cholangiocarcinoma.