Moreover, Mφs incubated with CAD PF-sEV showed significantly lower levels of anti-inflammatory CD206+/high, CD36+/high, CD163+, and CD169+ markers compared with control Mφs (Untouched and PBS) and Mφs incubated with non-CAD PF-sEV (Figures 3A to 3D, Supplemental Figure 4). Here, SIGLEC1 is linked to coronary artery disorder.