The biological molecular findings that allow ameloblastoma to invade surrounding tissues involve alterations in the RANK/RANKL/OPG pathways, transforming growth factor beta (TGF-β), Wnt/β-catenin pathway, and matrix metalloproteinases, as well as alterations in MAPK and SHH pathways that facilitate the proliferation and tumor development of ameloblastoma. Here, SHH is linked to ameloblastoma.