They have been described in patients with CIS suggestive of MS,50 but not in MS mimics, including NMOSD, Susac syndrome, and SVD.50, 51, 52 The presence of at least one PRL was found the optimal cut-off to distinguish CIS/MS patients from MS mimickers and old healthy subjects with a high specificity (99.7%) but low sensitivity (24.0%) and area under the curve [AUC] = 0.71). The gene discussed is PRL; the disease is in situ carcinoma.