Treatment with the second-generation ACEI analog enalapril in a rat model reduced ROS, p38MAPK, and TGF-β (Zhou et al., 2020) protein expression, blocked Ang II-induced cardiac fibroblast proliferation, and attenuated myocardial fibrosis (Yu et al., 2012). The gene discussed is AGT; the disease is Myocardial fibrosis.