CEA can also be used as a homotypic or heterotypic adhesion molecule, or in combination with signaling receptors such as DR5 receptors and transforming growth factor-β receptors, which can affect tumor cells or the surrounding interstitial and immune compartments to change their signaling programs to support metastatic progress (Beauchemin and Arabzadeh, 2013). This evidence concerns the gene CEACAM5 and neoplasm.