Given the observed distinct differences in CD19 MFI and in the proportions of CD11c + CXCR5-, CD11c-CXCR5+, and CD11c-CXR5- B cells particularly in the DN subset when SLE were compared with HD, we tested whether we could identify relations between these markers focusing on SLE samples. Here, CXCR5 is linked to Huntington disease.