While in lupus two DN populations were originally described DN1 CXCR5+CD11c- and DN2 CXCR5-CD11c+, additional DN3 CXCR5-CD11c-have also been described in COVID-19 [15], SLE [16] and autoimmune fibrosis [18]. The gene discussed is ITGAX; the disease is systemic lupus erythematosus.