Similarly, when focusing on DN B cells (CD19+CD27-IgD-), SLE had significantly less DN1 (CD11c-CXCR5+) and significantly more DN2 (CD11c + CXCR5-) and DN3 (CD11c-CXCR5-) than HD (Fig. 2C). The gene discussed is ITGAX; the disease is systemic lupus erythematosus.