The present study demonstrated that MOIG alleviated the paw swelling in CIA rats, inhibited the activities of FLSs activated by inflammatory cytokines via suppressing NF-κB and JAK2/STAT3 pathway by inhibition of GSK-3β, indicating that MOIG maybe has potential for the prevention and the treatment of RA. Here, NFKB1 is linked to rheumatoid arthritis.