To clarify the role of GSK-3β in RA, we performed the Gene Expression Omnibus (GEO) analysis of GSK-3β mRNA level based on RNA-seq data of RA patient from the National Center for Biotechnology Information data (GSE93777, GSE93272, and GSE56409), the results exhibited that the GSK-3β mRNA level was higher in the whole blood and synovium of RA patients than those of healthy population (P< 0.001) (Figures 6A–C). Here, GSK3B is linked to rheumatoid arthritis.