MMP2 and Arthritis: As shown in Figure 3, treatment with MOIG significantly inhibited adhesion ability, wound healing, migration and invasion activity, and also the expression of MMP2, MMP3, and cell adhesion molecules cadherin 11, VCAM-1 and ICAM-1 in TNF-α-stimulated FLSs (P < 0.05, P < 0.01, P < 0.001) (Figures 3A–M), suggesting that MOIG suppressed the migration and invasion activities of FLSs, thereby inhibiting the spread of joint inflammation to distant joints.