NFKB1 and rheumatoid arthritis: In addition, monotropein, as the major plant metabolites of MOIG, has multiple bioactivities associated with RA, such as inhibitory effects on bone destroy induced by inflammation through suppressing the activation of NF-κB pathway in osteoblast and osteoclast; anti-nociceptive and anti-inflammatory effects, and chondroprotective activity in osteoarthritic rats by decreasing the proinflammatory cytokines through inhibition NF-κB pathway (Wu et al., 2023).