Due to its potent antioxidant effects, it has been reported that the Nrf2 signaling has been implicated in the pathogenesis of various diseases including cardiovascular diseases, brain diseases, kidney diseases, cancer et al. (Menegon et al., 2016; Tian et al., 2021; Liu Y. et al., 2022; He et al., 2024; Tang et al., 2024). The gene discussed is NFE2L2; the disease is brain disorder.