The major reported cause of the development of HCC to an advanced stage is the decreased expression of carcinoma-suppressing genes and enhanced expression of oncogenes, resulting in the successive development of HCC, which ultimately causes the sequential hyperactivation of an important enzyme known as Raf/MEK/extracellular signal-regulated kinase (ERK) (Avila et al., 2006). Here, MAP2K7 is linked to hepatocellular carcinoma.