Furthermore, multivariable logistic regression analysis suggested that age (OR=1.063, 95%CI 1.019-1.109, P=0.005), FPG (OR=1.508, 95%CI 1.066-2.134, P=0.020) and FINS (OR=1.213, 95%CI 1.010-1.455, P=0.038) were independent risk factors for thyroid nodules in type 2 diabetic mellitus, while IGF-1/IGFBP-3 ratio (OR<0.001, 95%CI <0.001-0.748, P=0.044) was inversely independent protective factors for thyroid nodules in type 2 diabetic mellitus (Table 5). This evidence concerns the gene IGFBP3 and diabetes mellitus.