IGFBP3 and thyroid nodule: Age (OR=1.082, 95%CI 1.030-1.136, P=0.002), FPG (OR=1.493, 95%CI 1.047-2.128, P=0.027), TSH (OR=1.493, 95%CI 1.002-2.225, P=0.049) and IGFBP-3 (OR=1.414, 95%CI 1.019-1.963, P=0.038) were independent risk factors for thyroid nodules in type 2 diabetic mellitus (Table 6).