The results indicated that IGF-1, IGFBP-3, and the IGF-1/IGFBP-3 ratio individually exhibited an uncertain predictive value for thyroid nodules in patients with T2DM (AUC=0.527, AUC=0.501, AUC=0.504, P>0.05) (Table 3). Here, IGFBP3 is linked to thyroid nodule.