This concern is furthermore supported by our previous findings using surgical resection specimens demonstrating heterogeneous T-cell distribution with prognostic value depending on T-cell location.7 CD8+ T-cell densities in the invasive margin showed a stronger association with survival compared to the tumor center.7,11 Since endoscopic forceps biopsies are taken from the tumor surface and do not reach the invasive margin, this will have an impact on the tumor representativeness and hence impact on the value of the T-cell markers that were identified in resection specimens. Here, CD8A is linked to neoplasm.