However, some cohorts merged in the LiverRisk score derivation cohort might not fully represent the general population/primary care setting, as they included pre-selected risk groups overlapping with the current study: one study included only patients from hospital liver clinics and alcohol rehabilitation centers,18 another included only patients with risk factors for CLD (alcohol abuse, diabetes, and elevated ALT),19 and a third included only patients with known metabolic risk factors.20 The gene discussed is GPT; the disease is congenital secretory chloride diarrhea 1.