MAPT and Alzheimer disease: Neuronal excitability changes are influenced by the two major hallmarks of AD, Aβ (Busche et al., 2012; Busche et al., 2008) and tau pathology (Busche et al., 2019; Crimins et al., 2012), whilst conversely, excitability changes have also been shown to drive both the deposition of both of these AD hallmark pathologies (Cirrito et al., 2005; Pooler et al., 2013; Wu et al., 2016; Yamamoto et al., 2015).