PI3K mutation presence was associated with tumor size and clinical stage at diagnosis (p = 0.04 and p = 0.027, respectively, but if we omitted metastatic disease in the analyses and we did not find statistical significance (p = 0,738), we did not found relation with endocrine receptors presence (p = 0.909) nor with IHQ or FISH HER-2 positive (p = 0.466). The gene discussed is PIK3CA; the disease is neoplasm.