A meta-analysis found that PI3K mutation was an independent negative prognostic factor (HR = 1.67, 95% CI 1.15–2.43, p = 0.007) [20], contrary to Buttita et al., who described a higher number of mutations in lobular versus ductal histology (40% vs. 20%, respectively); [44, 51] did not find a correlation between tumor histology and mutations. Here, PIK3CA is linked to neoplasm.