These results are in line with OD where elevated ALP activity is reported in mature osteoblasts and is positively correlated with mineralization rate.[41, 42] For late osteogenic markers (OPN, OCN), higher expression was observed for OM+ and GM+ after only seven days of culture, and were stable overtime compared to the OM control (Figure 1B). This evidence concerns the gene SPP1 and ocular melanoma.