The results of qPCR showed that the expression levels of most microdomain genes (Sgip1, Nrxn1, Gpr158, Aak1, Rufy3, Necap1, and Hepacam) were increased after the stroke via administration of EV‐circSCMH1; only 5 microdomain genes (Sgip1, Nrxn1, Aak1, Necap1, and Hepacam) showed downregulated expression levels after circSCMH1‐mediated intervention in DDX1 knockdown mice (Figure 6H). The gene discussed is HEPACAM; the disease is Stroke.