TGFB1 and glomerulosclerosis: IRI mice also presented with significantly increased interstitial kidney fibrosis (by 2.1-fold; Fig. 4C and H), glomerulosclerosis (by one-fold; Fig. 4D and I), interstitial myofibroblast accumulation (by 4.5-fold; Fig. 4E and J) and TGF-β1 levels (by 0.6-fold; Fig. 4K) at 7-day post-injury, compared to that measured in sham controls.