APC and neoplasm: Irrespective of genetic alteration of Apc, causal to carcinogenesis we observed that the protein level of USP10 was significantly upregulated in tumours within the GI tract, along with elevated protein levels of β-Catenin, when compared to non-transformed or non-oncogenic intestinal epithelium, respectively (Fig. 2e, f and Supplementary Fig. S2e, f).