CTNNB1 and colorectal carcinoma: While USP10 was rarely mutated in CRC, it was predominantly upregulated, along with CTNNB1, when compared to adjacent wild-type tissue (Fig. 1d and Supplementary Fig. S1c), and USP10 and CTNNB1 demonstrated a significant degree of correlation of expression in CRC samples (Fig. 1e, nT = 275, nWT = 349, Spearman coefficient R = 0.79).