LSR is present not only in the gastrointestinal tract, but also in other COVID-19-relevant cell types such as the lungs, the liver, and the endothelium et al. Thus, whether regulation of Spike and ACE2 interaction through LSR represents a general mechanism, extending beyond intestinal epithelial cells, are important questions that need to be addressed in future studies. Here, CHMP5 is linked to COVID-19.