TP53 and cancer: The elucidation of the crystal structure of the central region of p53 and the identification of this domain as a specific DBD then provided an explanation for the above findings and led to this simple binary classification of common cancer mutations as contact mutations that disrupt amino acids directly contacting DNA (at codons 273 and 248) and structural mutations that destabilize the structure/conformation of the DBD (at codons 175, 249, or 282) [20–22].