In children, previous studies have focused on cardiac diseases such as heart failure, congenital heart disease, and Kawasaki disease in children, but rare studies have investigated the relationship between BNP and non-cardiac diseases.10,28,29 Our subgroup analysis showed that high BNP levels remain associated with all-cause mortality even in critically ill children with noncardiac diseases. The gene discussed is NPPB; the disease is Kawasaki disease.