Based on 210 patients’ age, gender, diabetes, hypertension, BMI, platelet, hemoglobin, tumor size, Ki-67, CRP, NLR, PLR, LMR, tumor necrosis, positive surgical margin, surgical mode, pathological type, AJCC stage, Fuhrman grade, SII and PNI, 9 independent risk factors were screened out from 21 factors by LASSO analysis and multivariate Cox regression analysis, which were SII, PNI, tumor size, tumor necrosis, surgical mode, pathological type, CRP, AJCC stage and Fuhrman grade, respectively, as shown in Fig. 5; Table 2. This evidence concerns the gene MKI67 and diabetes mellitus.