Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) are multifactorial debilitating diseases of the nervous system involving misfolding and accumulation of aggregated proteins, mainly including tau and α-SYN. Here, MAPT is linked to amyotrophic lateral sclerosis.