MYC and hepatocellular carcinoma: (G) Alternative splicing: Zhou demonstrated that an intron 3 retention transcript of lncRNA PXN-AS1 (PXN-AS1-IR3) recruits p300 to the MYC promoter, activating MYC downstream genes and facilitating hepatocellular carcinoma (HCC) metastasis (Fig. 1G) [21].