In human endometrium, expression of GATA2 and PGR also show a strong positive correlation, while loss of GATA2 expression may be a defining feature of both adenomyosis and endometriosis, possibly in conjunction with increased expression of GATA6, with both GATA family members postulated to play a role in endometriosis pathogenesis [17, 18]. This evidence concerns the gene GATA6 and adenomyosis.