Regarding gene polymorphisms, it was reported that the most important single nucleotide CAT polymorphism −262C > T (rs1001179) may reduce the enzymatic activity of CAT, and the CAT mutant T allele remains the highest independent risk factor for MASH development (Huang et al. 2021; Kosmalski et al. 2023). This evidence concerns the gene CAT and metabolic dysfunction-associated steatohepatitis.