NQO1 and metabolic dysfunction-associated steatotic liver disease: Moreover, many other studies reported significant downregulation of hepatic NQO1 protein levels in various animal MASLD models (Dong et al. 2018; Jin et al. 2021; Pan et al. 2024; Xia et al. 2016; Ye et al. 2022; Zhao et al. 2018b).