In various diet-induced animal models of MASLD, downregulation of hepatic NQO1 mRNA levels was reported (Ke et al. 2022; Xu et al. 2021; Zilu et al. 2019), while no significant changes were found in several other studies (Yu et al. 2021; Zheng et al. 2021). This evidence concerns the gene NQO1 and metabolic dysfunction-associated steatotic liver disease.