A study of the frequency of 1183 T/C polymorphism of SOD2 in Japanese MASH patients revealed a higher incidence of the T/T genotype in the mitochondrial targeting sequence of this gene, resulting in the less effective targeting of Mn-SOD to mitochondria in these patients (Namikawa et al. 2004). The gene discussed is SOD2; the disease is metabolic dysfunction-associated steatohepatitis.