Notably, while PLXNB1 was not associated with the overall survival of patients with CRC, high SEMA4D expression was associated with significantly decreased overall survival, suggesting that Epi‐11 may not be directly involved in tumorigenesis through PLXNB1, but may promote LM development by interacting with SEMA4D on mast and T/NK cells. Here, SEMA4D is linked to colorectal carcinoma.