Additionally, because of their small size, which allows for rapid diffusion and systemic effects, and their effects on neuromuscular and neurovascular function, sPLA2s have been implicated in lethal effects of SBE.14, 16 The wide occurrence, abundance and severity of pathology resulting from sPLA2s make this toxin family a promising therapeutic target. This evidence concerns the gene PLA2G2D and subacute bacterial endocarditis.