ANGPT2 and chronic kidney disease: David et al. reported an inverse relationship between serum Ang-2 levels and eGFR in patients with CKD, and showed that circulating Ang-2 levels increased in patients with stage 1-5 CKD and patients on dialysis, and also reported that Ang-2 levels increased shortly after nephrectomy in a group of 15 healthy renal donors and correlated with a decrease in eGFR.