Increased Ang-2 levels may result from excessive WPB exocytosis because of decreased nitric oxide in patients with CKD.23 Yang et al. reported higher serum Ang-2 levels in peritoneal dialysis patients than in healthy individuals, suggesting that increased Ang-2 levels resulted from excessive WPB exocytosis because of decreased nitric oxide production. This evidence concerns the gene ANGPT2 and kidney failure.