Based on the high proportion of patients in our study found to have a diagnosis of AQP4-IgG seropositive NMOSD or MOGAD, and that MOGAD can account for a substantial proportion of patients with pure spinal cord gray matter involvement on MRI,30 we view the “gray matter” vs “white matter” myelitis distinction as insufficient for use in contemporary clinical practice. This evidence concerns the gene AQP4 and myelitis.