MUC12 and cancer: Previously, its expression was found to be significantly lower in colorectal cancer tissues, indicative of potential tumor suppressor activity.58 In contrast, other research suggested that MUC12 was overexpressed in renal cell carcinoma.59 Its high significance is influenced by its long length (5,478 amino acids), and the effect size is relatively small, but our results suggest that there may be a tendency of structurally damaging missense mutations in this protein to drive cancer.