In a total of 63 pSS patients, there was no significant correlation observed between anti-AQP5 (26.42 (24.07, 28.08) ng/ml) levels and anti-SSA (200.00 (94.90, 200.00) IU/ml), anti-SSB (101.00 (6.47, 400.00) IU/ml), ANA (320.00 (320.00, 1000.00)), RF (20.00 (20.00, 51.50) IU/ml), anti-ds-DNA (25.00 (25.00, 42.00) IU/ml), complement 3 (0.78 (0.67, 0.88) g/l), or lymphocyte count (1.32 (0.83, 1.84)) levels (P > 0.05). This evidence concerns the gene AQP5 and peeling skin syndrome.