In addition, the study of Lin et al. [24] in the lung cancer showed that ADAM9 overexpression mediated t-PA activation to enhance the expression of CDCP1, suggesting that the ADAM9/CDCP1/t-PA pathway plays a synergistic role in the development of lung cancer and that the high expressions of these three biological molecules are associated with poor prognosis of patients. This evidence concerns the gene ADAM9 and lung cancer.