In addition, the study of Lin et al. [24] in the lung cancer showed that ADAM9 overexpression mediated t-PA activation to enhance the expression of CDCP1, suggesting that the ADAM9/CDCP1/t-PA pathway plays a synergistic role in the development of lung cancer and that the high expressions of these three biological molecules are associated with poor prognosis of patients. The gene discussed is PLAT; the disease is lung carcinoma.