Also, the previous reports stated the detrimental effects of BPA on the brain tissue of AD models and human macrophage cells; this toxic effect is expressed by elevated TNF-α and IL-1β (Chen et al. 2018; Sukjamnong et al. 2020; Engin and Engin 2021), thus may explain the neurodegenerative role of BPA. The gene discussed is IL1B; the disease is Alzheimer disease.