CKB and hypothyroidism: 2014). It acts as a potent vasodilator, expanding thyroid inter-follicular capillaries to facilitate thyroid hormone synthesis and secretion (Nagasaki et al. 2014). Some reports link serum creatine kinase expression, hypothyroidism, and TSH concentrations (mostly in human case studies like Scott et al. (2002); Ranka and Mathur (2003)), which has not been shown in rodents. We found the creatine kinase B (Ckb) expression upregulated in PTU-treated samples in a dose-dependent manner.