Interleukin-6 (IL-6), one of the most involved in CRS, among others (TNF-alpha, IFN-gamma, nitric oxide (NO), nitric oxide species (NOS), and reactive oxygen species (ROS) have been implicated in the development of arrhythmias, ventricular dysfunction, and other cardiac abnormalities [11, 12]. Here, IL6 is linked to congenital rubella syndrome.