Emerging studies underscore ERRα’s pivotal function in maintaining renal integrity, primarily through modulating mitochondrial structure and bioenergetics within PTCs.[6] The downregulation of ERRα in these cells has been linked to a spectrum of renal insults, suggesting its protective role against cellular damage.[6, 7, 8, 9] Despite these insights, the specific mechanisms through which ERRα expression is regulated in DKD have yet to be fully delineated. This evidence concerns the gene ESRRA and diabetic kidney disease.