PPARGC1A and diabetic kidney disease: These findings underscore the pivotal role of mitochondrial injury within PTCs in DKD pathogenesis.[15] Mitochondrial integrity in PTCs was further examined, revealing markedly reduced expression of the mitochondrial markers TOM20 and PGC1α, key components of mitochondrial function and biogenesis, respectively, in DKD‐affected kidneys, aligned with LTL‐positive proximal tubules (Figure S1G–I, Supporting Information).