Notably, carnosic acid has been identified as an inhibitor of osteoporosis by targeting the ubiquitin‐mediated degradation pathway of ERRα.[48] Similarly, FBXL10 has been shown to enhance the mono‐ubiquitination of ERRα, thereby fostering the proliferation of breast cancer cells.[49] Additionally, the mTOR pathway has been implicated in the modulation of ERRα activity via the UPS, affecting the progression of nonalcoholic fatty liver disease (NAFLD).[13]. Here, ESRRA is linked to osteoporosis.