ESRRA and early-onset autosomal dominant Alzheimer disease: ERRα, pivotal in cellular metabolism and mitochondrial integrity, stands at the forefront of research into metabolic disorders.[28, 29] This transcription factor's expression varies across diseases, with increased levels linked to poor outcomes in several cancers, including breast cancer, where it correlates with osteoporosis.[30, 31] Conversely, diminished ERRα expression has been implicated in vascular inflammation,[32] acute lung injury,[33] Alzheimer's disease,[34] and heart failure,[35] highlighting its broad physiological relevance.