As shown in Fig. 1A, the 15A7.5 mAb was chosen from a set of preselected anti-human nectin-4 antibodies, including clone 5A12.2 (Supplementary Table S1), because of a lower EC50 value for cellular binding on keratinocytes than to tumor cell lines SUM190, T47D, and MDA-MB231-N4+. Here, NECTIN4 is linked to neoplasm.