Recent studies demonstrated that among the six proteins of C. neoformans (Cda1, Cda2, Cda3, Fpd1, MP88, and Sod1), expressed in recombinant forms, loaded into glucan particles and used to vaccinate mice, four could protect mice from lethal dose infection with C. neoformans (31), as did synthetic peptides derived from Cda2 (32). This evidence concerns the gene AICDA and infection.