We analyzed the interactions of potential therapeutic targets of H. cordata against NSCLC and identified five core components (quercetin, kaempferol, 2-undecanone, isoramanone, and dodecanal) and eight key targets (IL6, MMP9, PPARG, ICAM1, SELE, MMP3, MMP1, and ALOX5). This evidence concerns the gene ICAM1 and non-small cell lung carcinoma.