It is elucidated that H. cordata may regulate pathways such as lipid and atherosclerosis, the TNF signaling pathway, and the IL-17 signaling pathway by acting on key targets such as IL6, MMP9, PPARG, ICAM1, SELE, IMMP3, IMMP1, and ALOX5 via its core components: quercetin, kaempferol, 2-undecanone, isoramanone, and dodecanal. Here, ICAM1 is linked to atherosclerosis.