Apolipoprotein B is the primary apolipoprotein and is the carrier for other lipids,[41] and urea is the main nitrogenous end product of protein metabolic decomposition.[42] However, protein and lipid intake in Africa is generally lower than that in Eurasia, so we speculate that insufficient and uniquely nutrient intake may be one of the factors for colorectal cancer to be affected by apolipoprotein B and urea in African populations. The gene discussed is APOB; the disease is colorectal cancer.