These seven selected features were used in the multivariate Cox regression analysis which identified several independent prognostic factors for OS in HCC patients after local ablation: ALP (HR: 1.002, 95% CI: 1.001–1.004, p = 0.015), preoperation AFP levels (HR: 1.904, 95% CI: 1.418–2.557, p = < 0.001), PNI (HR: 1.484, 95% CI: 1.082–2.036, p = 0.014), tumor number (HR: 1.781, 95% CI: 1.255–2.528, p = 0.001), tumor size (HR: 2.401, 95% CI: 1.787–3.227, p < 0.001) (Figure 2). The gene discussed is AFP; the disease is neoplasm.