Azevedo P.G., Miranda L.R., Nicolau E.S., Alves R.B., Bical-hoM.A.C., Couto P.P., Ramos A.V., Souza R.P., Longhi R., FriedmanE., Marco L., Bastos-Rodrigues L. Genetic association of thePERIOD3 (PER3) Clock gene with extreme obesity. This evidence concerns the gene PER3 and obesity due to melanocortin 4 receptor deficiency.