CENPA and cancer: At the moment, several mechanisms for the formation ofmetapolycentromeres were suggested: multiple Robertsoniantranslocations in the Indian muntjac (Huang L. et al., 2006),segmental duplications in legumes (Macas et al., 2023), epigeneticcharges in the interspecies marsupial hybrids (O’Neillet al., 1998) and expansion of centromeric chromatin and overexpressionof the CENP-A protein in the malignant neoplasms(Sullivan L.L. et al., 2011, 2016; Perpelescu et al., 2015).