DCTN1 and amyotrophic lateral sclerosis: Furthermore, we show that ALS patient iPS-MNs have a downregulation of the heavy subunit of dynactin/dynein, DCTN-1, reducing the speed of retrograde mitochondrial transport in TDP-43M337V and TDP-43I383T iPS-MNs, and this impairment can be improved by overexpression of DCTN-1 in patient iPS-MNs.