Siddiqui’s et al. (63) research showed that when the nerve growth factor (Ngfr) signal is induced and activated in the hippocampus of an AD pathological mouse model, it reduces the reactive glial state by inhibiting Lcn2/Slc22a17 signal transduction and enhances the neurotrophic function of astrocytes. This evidence concerns the gene LCN2 and Alzheimer disease.