CD8 T cells derived resolvable elements can activate the aforementioned tumor killing function of M1-type macrophages, simultaneously these M1-type macrophages in turn expressed CXCL9 and CXCL10, which in positive feedback to the T cell infiltration, augmented the response to T cell immunotherapy, and consequently raised the overall survival of the patients (Tokunaga et al., 2018). The gene discussed is CD8A; the disease is neoplasm.